The U.S. Customs House or U.S. Customshouse is the customs house in Charleston, South Carolina.
Construction began in 1852 but was interrupted in 1859 due to costs and the possibility of South Carolina's secession from the Union. After the Civil War, construction was restarted in 1870 and completed in 1879. The building was placed on the National Register of Historic Places on October 9, 1974. It is also a contributing property of the Charleston Historic District